Prevention of vitamin K deficiency in infancy by weekly administration of vitamin K

Acta Paediatr. 1993 Aug;82(8):656-9. doi: 10.1111/j.1651-2227.1993.tb18034.x.


Vitamin K prophylaxis has been developed to prevent classic haemorrhagic disease of the newborn. Single vitamin K administration after birth has been reported to fail, resulting in late haemorrhagic disease of the newborn. The preventive effect of oral administration of vitamin K1 1 mg, repeated weekly during the first three months of life, was studied in 48 healthy breast-fed infants, by determination of thrombotest, PIVKA-II and vitamin K1 concentrations at the age of 4, 8 and 12 weeks. All infants showed normal thrombotest values and PIVKA-II was not detectable. Vitamin K1 concentrations were negatively correlated with the number of days elapsed since the most recent vitamin K administration. Six to seven days after the latest application, mean levels were 1223, 927 and 748 pg/ml at ages 4, 8 and 12 weeks, respectively. In conclusion, weekly administration of vitamin K1 1 mg offers complete protection against vitamin K deficiency and does not result in an accumulation of vitamin K1 in the blood.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers*
  • Blood Proteins / analysis
  • Breast Feeding
  • Drug Evaluation
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Protein Precursors / analysis
  • Prothrombin / analysis
  • Prothrombin Time
  • Time Factors
  • Vitamin K / administration & dosage*
  • Vitamin K 1 / blood
  • Vitamin K Deficiency / blood
  • Vitamin K Deficiency / prevention & control*
  • Vitamin K Deficiency Bleeding / blood
  • Vitamin K Deficiency Bleeding / prevention & control


  • Biomarkers
  • Blood Proteins
  • Protein Precursors
  • Vitamin K
  • acarboxyprothrombin
  • Vitamin K 1
  • Prothrombin