Convenient syntheses of oligonucleotides linked to 5-deazaflavin coenzyme models at 3'-end. Incorporation of 5-deazaflavin to controlled pore glass (CPG) support

Chem Pharm Bull (Tokyo). 1993 Jul;41(7):1315-7. doi: 10.1248/cpb.41.1315.

Abstract

Using CPG support linked with 5-deazaflavin, the 5-deazaflavin modified oligodeoxynucleotides at 3'-end(ODN-dF1) were synthesized. The thermal stability of the duplex of ODN-dF1 with its complement was higher than that of oligonucleotide linked to 5-deazaflavin at 5'-end internucleotide linkage.

MeSH terms

  • Base Sequence
  • Coenzymes / chemistry*
  • DNA Probes / chemical synthesis
  • Flavins / chemistry*
  • Molecular Sequence Data
  • Oligonucleotides / chemical synthesis*

Substances

  • Coenzymes
  • DNA Probes
  • Flavins
  • Oligonucleotides
  • 5-deazaflavin