Anti-AIDS agents, 9. Suberosol, a new C31 lanostane-type triterpene and anti-HIV principle from Polyalthia suberosa

J Nat Prod. 1993 Jul;56(7):1130-3. doi: 10.1021/np50097a017.

Abstract

A new C31 lanostane-type triterpene, assigned the trivial name suberosol [1], has been isolated from Polyalthia suberosa as an anti-HIV principle. The structure has been characterized as 24-methylenelanost-7,9(11)-diene-3 beta, 15 alpha-diol (suberosol) [1], based on spectroscopic evidence. Compound 1 was found to show anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 3 micrograms/ml.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Cells, Cultured
  • HIV Core Protein p24 / immunology
  • HIV-1 / drug effects*
  • Humans
  • Lymphocytes / microbiology
  • Magnetic Resonance Spectroscopy
  • Plants, Medicinal / chemistry*
  • Steroids / chemistry
  • Steroids / isolation & purification
  • Steroids / pharmacology*

Substances

  • Antiviral Agents
  • HIV Core Protein p24
  • Steroids
  • suberosol