The centromere of budding yeast

Bioessays. 1993 Jul;15(7):451-60. doi: 10.1002/bies.950150704.


Stable maintenance of genetic information during meiosis and mitosis is dependent on accurate chromosome transmission. The centromere is a key component of the segregational machinery that couples chromosomes with the spindle apparatus. Most of what is known about the structure and function of the centromeres has been derived from studies on yeast cells. In Saccharomyces cerevisiae, the centromere DNA requirements for mitotic centromere function have been defined and some of the proteins required for an active complex have been identified. Centromere DNA and the centromere proteins form a complex that has been studied extensively at the chromatin level. Finally, recent findings suggest that assembly and activation of the centromere are integrated in the cell cycle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Base Sequence
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Cell Cycle
  • Centromere*
  • Chromosomes, Fungal / ultrastructure*
  • Consensus Sequence
  • DNA, Fungal / genetics
  • DNA-Binding Proteins / metabolism
  • Fungal Proteins / metabolism
  • Kinetochores
  • Kluyveromyces / cytology*
  • Kluyveromyces / genetics
  • Kluyveromyces / physiology
  • Meiosis
  • Mitosis
  • Molecular Sequence Data
  • Saccharomyces cerevisiae / cytology*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology
  • Saccharomyces cerevisiae Proteins*
  • Sequence Homology, Nucleic Acid


  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • CBF1 protein, S cerevisiae
  • CBF2 protein, S cerevisiae
  • DNA, Fungal
  • DNA-Binding Proteins
  • Fungal Proteins
  • Saccharomyces cerevisiae Proteins