Plasma triglycerides and lipoprotein(a): inverse relationship in a hyperlipidemic Italian population

Atherosclerosis. 1993 Jul;101(2):203-11. doi: 10.1016/0021-9150(93)90117-d.


The relationship between plasma lipoprotein(a) (Lp(a)) levels and other clinical/biochemical variables was investigated in 1200 consecutive hyperlipidemic patients. Plasma Lp(a) concentrations were measured by a sandwich-ELISA method, while the patients were either on diet or diet plus lipid-lowering drugs; 38% of them had a plasma Lp(a) level > 30 mg/dl. The median plasma Lp(a) concentration and the frequency of Lp(a) > 30 mg/dl were significantly lower in individuals with severe hypertriglyceridemia vs. hypercholesterolemics (HC) or mixed hyperlipidemics (M-HLP), but similar to normolipidemic healthy controls. Patients with isolated moderate hypertriglyceridemia had Lp(a) levels intermediate between HC and M-HLP subjects. The in vitro addition of triglyceride-rich lipoproteins to normotriglyceridemic plasma did not affect the Lp(a) measurement. Plasma Lp(a) concentrations in the whole hyperlipidemic population correlated negatively with triglycerides and positively with total cholesterol, HDL-cholesterol and age, being unrelated to either body mass index or lipid-lowering treatment. In HC patients, the presence of tendon xanthomas was associated with twofold higher Lp(a) levels. These findings argue for a regulatory role of triglycerides on plasma Lp(a) levels in hyperlipidemic patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Female
  • Humans
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / therapy
  • Hyperlipidemias / blood*
  • Hyperlipidemias / therapy
  • Hyperlipoproteinemia Type V / blood
  • Hyperlipoproteinemia Type V / therapy
  • Hypertriglyceridemia / blood
  • Hypertriglyceridemia / therapy
  • Italy
  • Lipoprotein(a) / blood*
  • Male
  • Middle Aged
  • Triglycerides / blood*


  • Cholesterol, HDL
  • Cholesterol, LDL
  • Lipoprotein(a)
  • Triglycerides
  • Cholesterol