Multiple genes for G protein-coupled receptors and their expression in lingual epithelia

FEBS Lett. 1993 Feb 1;316(3):253-6. doi: 10.1016/0014-5793(93)81302-g.

Abstract

Using the polymerase chain reaction (PCR), we identified a gene family including more than 60 members which encoded similar G protein-coupled seven-transmembrane receptors. Sequence analyses of six representatives out of the 60 PCR clones showed that they had significant structural similarity to olfactory and optic receptors. Their expression is restricted in the surface of lingual epithelia.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Epithelium / physiology
  • GTP-Binding Proteins / physiology*
  • Gene Expression
  • Molecular Sequence Data
  • Oligodeoxyribonucleotides / chemistry
  • RNA, Messenger / genetics
  • Rats
  • Receptors, Cell Surface / genetics*
  • Sequence Alignment
  • Taste / physiology
  • Tongue / physiology*

Substances

  • Oligodeoxyribonucleotides
  • RNA, Messenger
  • Receptors, Cell Surface
  • GTP-Binding Proteins