Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 361 (6410), 315-25

Inositol Trisphosphate and Calcium Signalling

Affiliations
Review

Inositol Trisphosphate and Calcium Signalling

M J Berridge. Nature.

Abstract

Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels displays the regenerative process of calcium-induced calcium release responsible for the complex spatiotemporal patterns of calcium waves and oscillations. Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling.

Similar articles

See all similar articles

Cited by 1,389 articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources

Feedback