Antagonistic modulation of human cytomegalovirus replication by transforming growth factor beta and basic fibroblastic growth factor

J Gen Virol. 1993 Feb;74 ( Pt 2):269-74. doi: 10.1099/0022-1317-74-2-269.

Abstract

We studied the effect of two cytokines, basic fibroblastic growth factor (bFGF) and transforming growth factor beta (TGF-beta) on human cytomegalovirus (HCMV) replication in cultured human lung fibroblasts. We show that TGF-beta increases HCMV production, probably by a transcriptional mechanism, and that bFGF represses HCMV replication in a dose-dependent manner. These actions were antagonistic and the mechanisms involved were independent of the effects of these factors on cell DNA synthesis and proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Cytomegalovirus / drug effects*
  • Cytomegalovirus / physiology
  • DNA Replication / drug effects
  • DNA, Viral / drug effects
  • Fibroblast Growth Factor 2 / pharmacology*
  • Fibroblasts
  • Humans
  • Transforming Growth Factor beta / pharmacology*
  • Virus Replication / drug effects*
  • Virus Replication / genetics

Substances

  • DNA, Viral
  • Transforming Growth Factor beta
  • Fibroblast Growth Factor 2