Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus

Neuropharmacology. 1993 Jan;32(1):1-9. doi: 10.1016/0028-3908(93)90123-k.


The transient activation of the N-methyl-D-aspartate (NMDA) receptor system by high frequency (tetanic) stimulation results in a rapidly developing and long-lasting potentiation of synaptic transmission in the CA1 region of the hippocampus. This potentiation can be divided into an early decremental component, known as short-term potentiation (STP), and a more slowly developing persistent phase, termed long-term potentiation (LTP). Here we describe how activation of metabotropic glutamate receptors (mGluRs), by aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R-ACPD), can induce the same stable form of LTP, but without the STP component. 1S,3R-ACPD-induced LTP does not require electrical stimulation during its induction, but is dependent on an intact connection between the CA3 and CA1 regions of the hippocampus. 1S,3R-ACPD-induced LTP circumvents the need for the activation of NMDA receptors and is likely to involve both the stimulation of protein kinase C (PKC) and the release of Ca2+ from intracellular stores.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / pharmacology
  • Animals
  • Calcium-Transporting ATPases / antagonists & inhibitors
  • Cycloleucine / analogs & derivatives
  • Cycloleucine / pharmacology
  • Electric Stimulation
  • Hippocampus / drug effects
  • Hippocampus / metabolism*
  • In Vitro Techniques
  • Neuronal Plasticity / drug effects*
  • Phosphatidylinositols / physiology
  • Protein Kinase C / antagonists & inhibitors
  • Protein Kinase C / metabolism
  • Rats
  • Receptors, Glutamate / drug effects*
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Signal Transduction / physiology
  • Staurosporine
  • Stereoisomerism
  • Synapses / drug effects
  • Synapses / metabolism
  • Terpenes / pharmacology
  • Thapsigargin


  • Alkaloids
  • Phosphatidylinositols
  • Receptors, Glutamate
  • Receptors, N-Methyl-D-Aspartate
  • Terpenes
  • Cycloleucine
  • 1-amino-1,3-dicarboxycyclopentane
  • Thapsigargin
  • Protein Kinase C
  • Calcium-Transporting ATPases
  • Staurosporine