Oral Magnesium Supplementation Restores the Concentrations of Magnesium, Potassium and Sodium-Potassium Pumps in Skeletal Muscle of Patients Receiving Diuretic Treatment

J Intern Med. 1993 Feb;233(2):117-23. doi: 10.1111/j.1365-2796.1993.tb00663.x.

Abstract

In 76 consecutive patients who had received diuretics for 1-17 years for arterial hypertension or congestive heart failure, muscle concentrations of magnesium, potassium, and sodium-potassium pumps were significantly reduced compared to 31 age- and sex-matched controls. Thirty-six patients with muscle magnesium and/or potassium below the control level received oral magnesium hydroxide supplement for 2-12 weeks (n = 20) or 26 weeks (n = 16). After short-term (2-12 weeks) magnesium supplementation muscle parameters were increased, but far from normalized. After magnesium supplementation for 26 weeks, the muscle concentrations of magnesium, potassium and sodium-potassium pumps were normalized in most cases. Oral magnesium supplementation may restore diuretic-induced disturbances in the concentrations of magnesium, potassium and sodium potassium pumps in skeletal muscle. A supplemental period of at least 6 months seems to be required before complete normalization can be expected.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Diuretics / adverse effects*
  • Female
  • Humans
  • Least-Squares Analysis
  • Magnesium / administration & dosage*
  • Magnesium / blood
  • Magnesium / metabolism*
  • Male
  • Middle Aged
  • Muscles / drug effects
  • Muscles / metabolism*
  • Ouabain / metabolism
  • Potassium / blood
  • Potassium / metabolism*
  • Receptors, Drug / drug effects
  • Receptors, Drug / metabolism
  • Sodium-Potassium-Exchanging ATPase / drug effects*

Substances

  • Diuretics
  • Receptors, Drug
  • cardiac glycoside receptors
  • Ouabain
  • Sodium-Potassium-Exchanging ATPase
  • Magnesium
  • Potassium