A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage

Mol Microbiol. 1993 Jan;7(1):99-107. doi: 10.1111/j.1365-2958.1993.tb01101.x.


Staphylococcus aureus strains isolated from patients with septic arthritis or osteomyelitis possess a collagen receptor present in two forms, which contains either two or three copies of a 187-amino-acid repeat motif. Collagen receptor-positive strains adhered to both collagen substrata and cartilage in a time-dependent process. Collagen receptor-specific antibodies blocked bacterial adherence, as did preincubation of the substrate with a recombinant form of the receptor protein. Furthermore, polystyrene beads coated with the collagen receptor bound collagen and attached to cartilage. Taken together, these results suggest that the collagen receptor is both necessary and sufficient to mediate bacterial adherence to cartilage in a process that constitutes an important part of the pathogenic mechanism in septic arthritis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arthritis, Infectious / microbiology*
  • Bacterial Adhesion*
  • Base Sequence
  • Cartilage, Articular / metabolism*
  • Cartilage, Articular / microbiology
  • Collagen / metabolism*
  • Humans
  • Microspheres
  • Molecular Sequence Data
  • Osteomyelitis / microbiology*
  • Protein Binding
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism*
  • Receptors, Collagen
  • Recombinant Fusion Proteins / metabolism
  • Staphylococcal Infections / microbiology*
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / isolation & purification
  • Staphylococcus aureus / metabolism*


  • Receptors, Cell Surface
  • Receptors, Collagen
  • Recombinant Fusion Proteins
  • Collagen