Expression of EBV/C3d receptors on T cells: biological significance

Immunol Today. 1993 Feb;14(2):56-9. doi: 10.1016/0167-5699(93)90059-T.


There is overwhelming evidence that a single polypeptide serves as a receptor for both the Epstein-Barr Virus (EBV), and for certain enzymatic fragments of C3. This receptor, termed CR2 (CD21), is known to be expressed on the surfaces of B cells, and a large body of evidence suggests that CR2, or related structures, are also expressed on cells of the T lineage. Here, Constantine Tsoukas and John Lambris review the studies of CR2 expression in T cells and offer some speculation on its possible biological significance.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / metabolism
  • B-Lymphocytes / microbiology
  • Herpesvirus 4, Human / metabolism*
  • Humans
  • Receptors, Complement 3d / biosynthesis*
  • Receptors, Virus / biosynthesis*
  • T-Lymphocytes / metabolism
  • T-Lymphocytes / microbiology*
  • Tumor Virus Infections / immunology
  • Tumor Virus Infections / metabolism


  • Receptors, Complement 3d
  • Receptors, Virus