Activation of mouse renin promoter by cAMP and c-Jun in a kidney-derived cell line

Biochim Biophys Acta. 1993 Mar 20;1172(3):306-10. doi: 10.1016/0167-4781(93)90218-3.

Abstract

We demonstrated that the mouse renin promoter from -365 to +16 can mediate the activation by cAMP and c-Jun in a kidney-cell dominant manner. Deletion analysis indicated that the region from -75 to -48 was responsible for the activation by cAMP. Furthermore, the core promoter region from -47 to +16 was sufficient to confer c-Jun inducibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cell Line
  • Cyclic AMP / pharmacology*
  • DNA Mutational Analysis
  • Gene Expression Regulation / drug effects*
  • Genes, jun*
  • Kidney
  • Mice
  • Molecular Sequence Data
  • Promoter Regions, Genetic
  • Renin / genetics*
  • Transfection

Substances

  • Cyclic AMP
  • Renin

Associated data

  • GENBANK/D13131
  • GENBANK/D13132
  • GENBANK/D13133
  • GENBANK/D13134
  • GENBANK/D13135
  • GENBANK/D13136
  • GENBANK/D13137
  • GENBANK/X73051
  • GENBANK/Z15111
  • GENBANK/Z15115