Translational Frameshifting in the Control of Transposition in Bacteria

Mol Microbiol. 1993 Feb;7(4):497-503. doi: 10.1111/j.1365-2958.1993.tb01140.x.

Abstract

The expression of an increasing number of genes of both prokaryotic and eukaryotic origin has been shown to be regulated at the translational level by programmed (sequence-specific) ribosomal frameshifting. Among these are the bacterial insertion sequences IS1 and two members of the widely distributed IS3-family, IS150 and IS911. Frameshifting provides a means of specifying several proteins with different functions using a minimum of genetic information. In this review, we survey present understanding of the way in which frameshifting is integrated into the overall control of transposition activity in these elements.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria / genetics*
  • Base Sequence
  • DNA Transposable Elements / genetics
  • Frameshift Mutation*
  • Gene Expression Regulation, Bacterial*
  • Molecular Sequence Data
  • Mutagenesis, Insertional / genetics*
  • Protein Biosynthesis*

Substances

  • DNA Transposable Elements

Associated data

  • GENBANK/M19676
  • GENBANK/M27276
  • GENBANK/M34841
  • GENBANK/X17348
  • GENBANK/X62936