Therapy for transplant-related lymphoproliferative diseases

Hematol Oncol Clin North Am. 1993 Apr;7(2):467-75.


Epstein-Barr virus can induce an uncontrolled B cell proliferation called B lymphocyte proliferative disorder (BLPD) in immunocompromised hosts. It is a complication that is increasing in prevalence with the growing frequency of transplantation. About 40% of BLPD are reversible following reduction of immunosuppressive therapy. In other instances, BLPD are often fatal with the exception of localized tumors that can be surgically excised. Therapeutic strategies have included antiviral drugs, alpha-interferon, and anti-B cell antibodies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes*
  • Herpesvirus 4, Human*
  • Humans
  • Lymphoproliferative Disorders / etiology
  • Lymphoproliferative Disorders / therapy*
  • Organ Transplantation / adverse effects*
  • Tumor Virus Infections / etiology
  • Tumor Virus Infections / therapy*