GABA rho 2 receptor pharmacological profile: GABA recognition site similarities to rho 1

Eur J Pharmacol. 1993 Mar 15;245(1):83-4. doi: 10.1016/0922-4106(93)90174-8.


The rho 2 receptor for gamma-aminobutyric acid (GABA) induces GABA-gated currents when expressed as a homooligomer in Xenopus oocytes. rho 2 responses display pharmacological profiles similar to those of expressed rho 1 receptors, although responses were slower, most agonists were more potent at rho 2 and Im values for the partial agonist imidazole-4-acetic acid were 7-fold higher. Amino acids important for most aspects of GABA agonist ligand recognition may not be among those that differ between rho 1 and rho 2, including the 20% amino acid difference in the N-terminal region.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cloning, Molecular
  • DNA
  • Oocytes
  • Receptors, GABA-A / drug effects*
  • Receptors, GABA-A / genetics
  • Receptors, GABA-A / metabolism
  • Xenopus


  • Receptors, GABA-A
  • DNA