[A Man With Spontaneous Regression of non-Hodgkin Lymphoma, Hypergammaglobulinemia and Infection Caused by 2 Herpesviruses; Causality or Coincidence?]

Ned Tijdschr Geneeskd. 1993 Apr 10;137(15):774-7.
[Article in Dutch]


A febrile illness with atypical peripheral blood lymphocytosis (polyclonal CD8+ suppressor/cytotoxic phenotype), complement activation and IgA/G class hypergammaglobulinaemia was found in a 76-year old male with clinical stage III follicular non-Hodgkin lymphoma (NHL). There was serological evidence of active cytomegalovirus (CMV) as well as reactivated chronic Epstein-Barr virus (EBV) infection. Spontaneous regression of NHL appeared, the signs of viral infection improved but hypergammaglobulinaemia persisted. In patients with malignant lymphoma, clinical signs and abnormalities of peripheral blood lymphocytes and serum immunoglobulins should not automatically be considered a consequence of the lymphoma.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Antibodies, Viral / isolation & purification
  • Cytomegalovirus / immunology
  • Herpesvirus 4, Human / immunology
  • Humans
  • Hypergammaglobulinemia / complications*
  • Lymphoma, Follicular / complications
  • Lymphoma, Follicular / physiopathology*
  • Male
  • Remission, Spontaneous


  • Antibodies, Viral