The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors

Oncogene. 1993 May;8(5):1293-301.


We have cloned a 4.2-kb murine cDNA encoding the Tek receptor tyrosine kinase (RTK), which is expressed in endothelial cells and their progenitors. The 1122-residue protein contains an extracellular domain comprising three fibronectin type III repeats fused to two immunoglobulin-like loops that are in turn separated by three epidermal growth factor-like repeats. The association of these different structural motifs and their characteristic arrangement in the Tek extracellular domain has been reported for only one other RTK, Tie, an endothelial-specific RTK of human origin. We show here that Tek and Tie are encoded by distinct genes and that, together, these receptors define a new subfamily of RTKs. In addition, we demonstrate that the tek cDNA, when introduced into COS cells, encodes a product of 140 kDa and that this protein and/or tek transcripts are detectable in highly vascularized embryonic tissues and in some, but not all, cell lines of endothelial origin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cells, Cultured
  • Cloning, Molecular
  • DNA / chemistry
  • Endothelium, Vascular / enzymology*
  • Gene Expression
  • Mice
  • Molecular Sequence Data
  • Protein-Tyrosine Kinases / genetics*
  • Proteins / analysis
  • Proteins / chemistry
  • Proteins / genetics*
  • Receptors, Cell Surface / genetics*
  • Receptors, Vascular Endothelial Growth Factor
  • Sequence Homology, Amino Acid


  • Proteins
  • Receptors, Cell Surface
  • DNA
  • Protein-Tyrosine Kinases
  • Receptors, Vascular Endothelial Growth Factor

Associated data

  • GENBANK/X67553