Differanisole A, an inducer of the differentiation of Friend leukemic cells, induces stalk cell differentiation in Dictyostelium discoideum

FEBS Lett. 1993 May 3;322(1):73-5. doi: 10.1016/0014-5793(93)81114-f.

Abstract

Differanisole A isolated from the conditioned medium of a soil microorganism, Chaetomium strain RB-001, is an inducer of the differentiation of the Friend leukemic cells (mouse leukemia cells). The chemical structure of this substance is very similar to that of stalk cell differentiation-inducing factor (DIF) isolated from the cellular slime mould, Dictyostelium discoideum. We examined the effects of differanisole A on Dictyostelium HM44 cells, a mutant strain which is defective in DIF production, and found this substance to be an inducer of stalk cell differentiation in D. discoideum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation / drug effects
  • Chlorobenzoates / chemistry
  • Chlorobenzoates / pharmacology*
  • Cyclic AMP / pharmacology
  • Dictyostelium / cytology
  • Dictyostelium / drug effects*
  • Hexanones / chemistry
  • Hexanones / pharmacology
  • Leukemia, Erythroblastic, Acute
  • Mice
  • Molecular Structure
  • Tumor Cells, Cultured

Substances

  • Chlorobenzoates
  • Hexanones
  • 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
  • differanisole A
  • Cyclic AMP