Complete nucleotide sequence of a coxsackie B5 virus and its relationship to swine vesicular disease virus

J Gen Virol. 1993 May;74 ( Pt 5):845-53. doi: 10.1099/0022-1317-74-5-845.

Abstract

We report the first complete nucleotide sequence of the picornavirus coxsackievirus B5 (CB5), strain 1954/UK/85, an isolate from a case of hand-foot-and-mouth disease. We have compared the sequence with those of other coxsackie B viruses, coxsackievirus A9, poliovirus and swine vesicular disease virus (SVDV). The genes encoding the three major capsid proteins are most closely related to those of SVDV but the 5' and 3' noncoding regions and the P3 gene are more similar to the corresponding regions in the other coxsackie B viruses than to those of SVDV. These observations are considered in the light of the antigenic and biochemical relationships between SVDV and CB5.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Capsid / genetics
  • Cell Line
  • DNA, Viral
  • Enterovirus / classification
  • Enterovirus / genetics*
  • Enterovirus B, Human / classification
  • Enterovirus B, Human / genetics*
  • Genome, Viral*
  • Hand, Foot and Mouth Disease / microbiology
  • Humans
  • Introns
  • Molecular Sequence Data
  • Papio
  • Peptides / genetics
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Swine
  • Swine Vesicular Disease / microbiology*
  • Viral Nonstructural Proteins / genetics

Substances

  • DNA, Viral
  • Peptides
  • Viral Nonstructural Proteins

Associated data

  • GENBANK/X67706