SV40 Induces Mesotheliomas in Hamsters

Am J Pathol. 1993 May;142(5):1524-33.

Abstract

In the course of studies to elucidate the relative contribution of simian virus 40 (SV40) large T and small t proteins during oncogenesis, we observed the appearance of pericardial and pleural tumors in 100% of Syrian hamsters injected in the pleural space with wild type SV40. When SV40 was injected via the intracardiac or intraperitoneal routes, more than 50% of hamsters developed mesothelial tumors. Macroscopic, microscopic, ultramicroscopic, and histochemical characteristics identify these neoplasms and derived cell lines as mesotheliomas and mesothelioma-derived cell lines. The SV40 genome was integrated and expressed in the mesotheliomas and derived cell lines. The absence of mesotheliomas in hamsters injected with SV40 small t deletion mutants indicates that the small t protein plays an important role in the development of SV40-induced mesotheliomas. To the best of our knowledge, this is the first definitive report of virus-induced mesotheliomas in mammals.

MeSH terms

  • Animals
  • Cricetinae / physiology*
  • Female
  • Gene Expression Regulation, Viral
  • Heart
  • Heart Neoplasms / etiology
  • Heart Neoplasms / genetics
  • Injections
  • Injections, Intraperitoneal
  • Male
  • Mesocricetus
  • Mesothelioma / etiology*
  • Mesothelioma / genetics
  • Mesothelioma / pathology
  • Microscopy, Electron
  • Peritoneal Neoplasms / etiology
  • Peritoneal Neoplasms / genetics
  • Pleura
  • Pleural Neoplasms / etiology
  • Pleural Neoplasms / genetics
  • Simian virus 40* / genetics
  • Tumor Cells, Cultured / physiology
  • Tumor Virus Infections / complications*