Spectrum of primary cutaneous CD30 (Ki-1)-positive lymphoproliferative disorders. A proposal for classification and guidelines for management and treatment

J Am Acad Dermatol. 1993 Jun;28(6):973-80. doi: 10.1016/0190-9622(93)70140-o.


Primary cutaneous CD30 (Ki-1)-positive, large cell lymphomas (LCLs) represent a recently recognized group of cutaneous T-cell lymphomas with a favorable prognosis. The characteristic features of this cutaneous lymphoma are reviewed, differences with primary noncutaneous CD30+ LCLs emphasized, and its relation with other CD30+ cutaneous lymphoproliferative disorders, in particular lymphomatoid papulosis, is discussed. These primary cutaneous CD30+ LCLs, lymphomatoid papulosis, and related conditions represent a clinical and histologic continuum. A classification with practical guidelines for the management and treatment of patients within this spectrum of lymphoproliferative disorders is presented.

Publication types

  • Review

MeSH terms

  • Antigens, CD*
  • Antigens, Neoplasm*
  • Humans
  • Ki-1 Antigen
  • Lymphoma*
  • Lymphoma, Large B-Cell, Diffuse*
  • Lymphoma, T-Cell, Cutaneous*
  • Lymphoproliferative Disorders / classification
  • Skin Neoplasms*


  • Antigens, CD
  • Antigens, Neoplasm
  • Ki-1 Antigen