The metabolism of [6-3H]1alpha, hydroxycholecalciferol to [6-3H]1alpha,25-dihydroxycholecalciferol in a patient with renal insufficiency

J Clin Endocrinol Metab. 1977 Mar;44(3):595-8. doi: 10.1210/jcem-44-3-595.


To evaluate whether 1alpha-hydroxycholecalciferol is metabolized to 1alpha,25-dihydroxycholecalciferol in man, [6-3H]1alpha-hydroxycholecalciferol was given intravenously to a patient with renal failure who was maintained daily on 100,000 IU vitamin D and calcium supplements. Using Sephadex LH-20 and high-pressure liquid chromatography, it was clearly demonstrated that 1alpha-hydroxycholecalciferol rapidly disappears from the blood and is metabolized to 1alpha,25-dihydroxycholecalciferol.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Dihydroxycholecalciferols / biosynthesis*
  • Female
  • Humans
  • Hydroxycholecalciferols / biosynthesis*
  • Hydroxycholecalciferols / metabolism*
  • Kidney Diseases / metabolism*
  • Middle Aged
  • Steroid Hydroxylases / metabolism


  • Dihydroxycholecalciferols
  • Hydroxycholecalciferols
  • Steroid Hydroxylases