Prophylactic and therapeutic vaccination against a mucosal papillomavirus

J Gen Virol. 1993 Jun;74 ( Pt 6):945-53. doi: 10.1099/0022-1317-74-6-945.

Abstract

Papillomaviruses are ubiquitous DNA viruses affecting humans and animals and causing a variety of tumours of mucosal and cutaneous epithelia. Some of these lesions, particularly those affecting mucosal epithelia, can progress to squamous cell carcinomas. Prevention or cure of viral infection would ultimately lead to a decrease in the incidence of papillomavirus-associated cancers. Using recombinant proteins, we have developed prophylactic and therapeutic vaccines against bovine papillomavirus type 4, a mucosal papillomavirus implicated in cancer of the alimentary canal in cattle; similar possibilities exist for the human mucosal papillomaviruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibody Formation
  • Bovine papillomavirus 1 / immunology
  • Bovine papillomavirus 1 / pathogenicity*
  • Capsid / genetics
  • Capsid / immunology
  • Cattle
  • Cattle Diseases / immunology
  • Cattle Diseases / prevention & control*
  • Gastrointestinal Neoplasms / immunology
  • Gastrointestinal Neoplasms / prevention & control*
  • Oncogene Proteins, Viral / genetics
  • Oncogene Proteins, Viral / immunology
  • Papilloma / immunology
  • Papilloma / prevention & control*
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / immunology
  • Specific Pathogen-Free Organisms
  • Tumor Virus Infections / immunology
  • Tumor Virus Infections / prevention & control*
  • Vaccination*
  • Vaccines, Synthetic / immunology*

Substances

  • Oncogene Proteins, Viral
  • Recombinant Fusion Proteins
  • Vaccines, Synthetic