An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1

J Virol. 1993 Jul;67(7):4391-4. doi: 10.1128/JVI.67.7.4391-4394.1993.


An open reading frame, LMW5-HL, in the African swine fever virus genome displays a high degree of similarity to the proto-oncogene bcl-2 and, to a lesser degree, the Epstein-Barr virus gene BHRF1. A highly conserved central region is found in all three proteins. LMW5-HL encodes a protein of 18 kDa that is present in infected porcine macrophages at both early and late times postinfection. The similarity of LMW5-HL to bcl-2 and BHRF1 suggests a role for it in cell maintenance during productive or persistent viral infection.

Publication types

  • Comparative Study

MeSH terms

  • African Swine Fever Virus / genetics*
  • Amino Acid Sequence
  • Apoptosis
  • Base Sequence
  • Genes, Viral*
  • Herpesvirus 4, Human / genetics*
  • Molecular Sequence Data
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-bcl-2
  • Proto-Oncogenes*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Viral Structural Proteins / genetics*


  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Viral Structural Proteins

Associated data

  • GENBANK/L09548