Priming of homosynaptic long-term depression in hippocampus by previous synaptic activity

Neuroreport. 1993 May;4(5):591-4. doi: 10.1097/00001756-199305000-00034.


Mechanisms regulating long-lasting, activity-dependent decreases in synaptic strength are poorly understood. Theoretical studies have suggested that the critical level (threshold) of synaptic activity needed to induce long-term depression (LTD) versus potentiation (LTP) of synaptic transmission should vary as a function of previous synaptic activity. In order to determine whether such a 'sliding threshold' is indeed a physiological phenomenon, we stimulated Schaffer collateral afferents in area CA1 of rat hippocampal slices at frequencies from 1 to 5 Hz before or after inducing LTP.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Electric Stimulation
  • Evoked Potentials / physiology
  • Hippocampus / cytology
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Male
  • Neuronal Plasticity / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Synapses / physiology*
  • Synaptic Transmission / physiology


  • Receptors, N-Methyl-D-Aspartate