Lack of preferential V beta usage in synovial T cells of rheumatoid arthritis patients

Immunol Res. 1993;12(1):12-20. doi: 10.1007/BF02918365.

Abstract

The T-cell receptor V beta subfamily repertoires of synovial and peripheral T cells of 8 rheumatoid arthritis (RA) patients were determined using the polymerase chain reaction. Three normal controls were included. Some of the rheumatoid synovial samples did not express the complete range of V beta families and lacked as many as 6 gene families. However, these patients showed considerable individual variation in expression. Overall, the data do not support preferential T-cell receptor V beta usage in synovial T cells of RA patients either in comparison to their autochthonous peripheral T cells or to peripheral T cells of normal subjects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / pathology
  • Base Sequence
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor*
  • Humans
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Receptors, Antigen, T-Cell, alpha-beta / genetics*
  • Synovial Membrane / pathology*
  • T-Lymphocytes*

Substances

  • Receptors, Antigen, T-Cell, alpha-beta