Estrogen metabolism and human papillomavirus-induced tumors of the larynx: chemo-prophylaxis with indole-3-carbinol

Anticancer Res. Mar-Apr 1993;13(2):337-41.

Abstract

A relationship was established between estradiol 16 alpha-hydroxylation, papillomavirus and its malignant sequelae. In this study, we determined that 16 alpha-hydroxylation was substantial in normal larynx and further increased in laryngeal papillomas. Estradiol or 16 alpha-hydroxyestrone stimulated proliferation in both kinds of cells while 2-hydroxyestrone was antiproliferative. Indole-3-carbinol, which induces 2-hydroxylation, abrogated the proliferative effects of estradiol. In immunocompromised mice, papilloma cysts formed in HPV-11 infected laryngeal tissue implanted under the renal capsules in 100% of control mice but only in 25% of mice fed indole-3-carbinol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticarcinogenic Agents / therapeutic use*
  • Aryl Hydrocarbon Hydroxylases*
  • Cell Division / drug effects
  • Cytochrome P-450 CYP2C8
  • Cytochrome P-450 CYP2C9
  • Estrogen Antagonists / pharmacology
  • Estrogen Antagonists / therapeutic use*
  • Estrogens / metabolism*
  • Female
  • Humans
  • Hydroxyestrones / pharmacology
  • Hydroxylation / drug effects
  • Indoles / therapeutic use*
  • Laryngeal Neoplasms / metabolism*
  • Laryngeal Neoplasms / microbiology
  • Laryngeal Neoplasms / prevention & control*
  • Larynx / drug effects
  • Larynx / metabolism
  • Male
  • Mice
  • Mice, Inbred Strains
  • Mice, Nude
  • Mixed Function Oxygenases / metabolism
  • Neoplasms, Hormone-Dependent / metabolism*
  • Neoplasms, Hormone-Dependent / microbiology
  • Neoplasms, Hormone-Dependent / prevention & control*
  • Papilloma / immunology
  • Papilloma / metabolism*
  • Papilloma / prevention & control
  • Papillomaviridae*
  • Steroid 16-alpha-Hydroxylase
  • Transplantation, Heterologous
  • Tumor Virus Infections / complications*

Substances

  • Anticarcinogenic Agents
  • Estrogen Antagonists
  • Estrogens
  • Hydroxyestrones
  • Indoles
  • 16-hydroxyestrone
  • indole-3-carbinol
  • Mixed Function Oxygenases
  • CYP2C9 protein, human
  • Cytochrome P-450 CYP2C9
  • Aryl Hydrocarbon Hydroxylases
  • CYP2C8 protein, human
  • Cytochrome P-450 CYP2C8
  • Steroid 16-alpha-Hydroxylase