Bombesin receptor antagonists differentiate receptor subtypes in rat brain

Eur J Pharmacol. 1993 Apr 22;235(1):121-5. doi: 10.1016/0014-2999(93)90830-b.


Previous studies have shown that various bombesin receptor antagonists can distinguish between bombesin receptor subtypes in peripheral tissues. To determine whether these antagonists would be useful in differentiating bombesin receptor subtypes in the rat central nervous system, we used in vitro receptor autoradiography to examine the binding affinities of several bombesin receptor antagonists for two brain regions we had characterized as possessing distinct bombesin receptor subtypes. Our results demonstrate that, consistent with peripheral bombesin receptors, bombesin receptor subtypes in the rat brain can be differentiated by various bombesin receptor antagonists.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Autoradiography
  • Binding Sites
  • Bombesin / analogs & derivatives
  • Bombesin / metabolism*
  • Brain / metabolism*
  • Gastrin-Releasing Peptide
  • In Vitro Techniques
  • Male
  • Neurokinin B / analogs & derivatives*
  • Neurokinin B / metabolism
  • Peptides / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Bombesin
  • Receptors, Neurotransmitter / antagonists & inhibitors*
  • Receptors, Neurotransmitter / metabolism


  • Peptides
  • Receptors, Bombesin
  • Receptors, Neurotransmitter
  • Gastrin-Releasing Peptide
  • Neurokinin B
  • neuromedin B
  • Bombesin