Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 364 (6434), 208-13

Molecular Basis of the Little Mouse Phenotype and Implications for Cell Type-Specific Growth

Affiliations

Molecular Basis of the Little Mouse Phenotype and Implications for Cell Type-Specific Growth

S C Lin et al. Nature.

Abstract

The molecular basis for the little (lit) mouse phenotype, characterized by a hypoplastic anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the growth hormone releasing factor receptor. Detailed analysis of the lit mouse anterior pituitary reveals spatially distinct proliferative zones of growth hormone-producing stem cells and mature somatotrophs, each regulated by a different trophic factor. This sequential growth factor requirement for a specific cell type may exemplify a common strategy for regulating cellular proliferation in other mammalian organs.

Comment in

Similar articles

See all similar articles

Cited by 77 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

Substances

LinkOut - more resources

Feedback