CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF

Cell. 1993 Jul 2;73(7):1349-60. doi: 10.1016/0092-8674(93)90361-s.


CD30 is a surface marker for neoplastic cells of Hodgkin's lymphoma and shows sequence homology to members of the tumor necrosis factor (TNF) receptor superfamily. Using a chimeric probe consisting of the extracellular domain of CD30 fused to truncated immunoglobulin heavy chains, we expression cloned the cDNA cognate from the murine T cell clone 7B9. The encoded protein is a 239 amino acid type II membrane protein whose C-terminal domain shows significant homology to TNF alpha, TNF beta, and the CD40L. Cross-hybridization to an induced peripheral blood T cell cDNA library yielded the human homolog, which is 72% identical at the amino acid level. The recombinant human ligand enhances the proliferation of CD3-activated T cells yet induces differential responses, including cell death, in several CD30+ lymphoma-derived clones. The human and murine genes map to 9q33 and the proximal region of chromosome 4, respectively.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, CD / metabolism*
  • Antigens, Neoplasm / metabolism*
  • Base Sequence
  • Binding, Competitive
  • Biomarkers, Tumor / metabolism
  • CD30 Ligand
  • Chromosome Mapping
  • Cytokines / chemistry
  • Cytokines / genetics*
  • Hodgkin Disease / immunology
  • Hodgkin Disease / metabolism*
  • Humans
  • Ki-1 Antigen
  • Ligands
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / genetics*
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Recombinant Proteins / chemistry
  • Recombinant Proteins / metabolism
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Tumor Necrosis Factor-alpha / chemistry
  • Tumor Necrosis Factor-alpha / genetics*


  • Antigens, CD
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • CD30 Ligand
  • Cytokines
  • Ki-1 Antigen
  • Ligands
  • Membrane Glycoproteins
  • Recombinant Proteins
  • TNFSF8 protein, human
  • Tnfsf8 protein, mouse
  • Tumor Necrosis Factor-alpha

Associated data

  • GENBANK/L09219
  • GENBANK/L09220
  • GENBANK/L09221
  • GENBANK/L09222
  • GENBANK/L09223
  • GENBANK/L09224
  • GENBANK/L09225
  • GENBANK/L09753
  • GENBANK/L09754
  • GENBANK/L33709