A Novel Method to Stabilise Antisense Oligonucleotides Against Exonuclease Degradation

Nucleic Acids Res. 1993 Jun 25;21(12):2957-8. doi: 10.1093/nar/21.12.2957.

Abstract

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Drug Stability
  • Exonucleases / metabolism*
  • Humans
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Oligonucleotides, Antisense / blood
  • Oligonucleotides, Antisense / chemistry
  • Oligonucleotides, Antisense / metabolism*

Substances

  • Oligonucleotides, Antisense
  • Exonucleases