Oxygen-dependent reduction of a nitroxide free radical by electron paramagnetic resonance monitoring of circulating rat blood

V Quaresima; C L Ursini; G Gualtieri; A Sotgiu; M Ferrari

doi:10.1016/0925-4439(93)90161-s

Oxygen-dependent reduction of a nitroxide free radical by electron paramagnetic resonance monitoring of circulating rat blood

Biochim Biophys Acta. 1993 Aug 4;1182(1):115-8. doi: 10.1016/0925-4439(93)90161-s.

Authors

V Quaresima¹, C L Ursini, G Gualtieri, A Sotgiu, M Ferrari

Affiliation

¹ Department of Sciences and Biomedical Technologies, University L'Aquila, Italy.

PMID: 8394142
DOI: 10.1016/0925-4439(93)90161-s

Abstract

The effects of fraction of inspired oxygen (FiO2) on the reduction of a nitroxide free radical were studied by X-band electron paramagnetic resonance (EPR) monitoring of circulating rat blood. The decay half-life of the metabolism/elimination phase increased significantly by 24 +/- 8% during hyperoxia and decreased significantly by 16 +/- 4% during hypoxia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cyclic N-Oxides / chemistry
Electron Spin Resonance Spectroscopy
Free Radicals
Hypoxia / blood*
Nitrogen Oxides / blood*
Nitrogen Oxides / chemistry
Oxidation-Reduction
Oxygen / blood*
Rats
Spin Labels

Substances

Cyclic N-Oxides
Free Radicals
Nitrogen Oxides
Spin Labels
proxyl nitroxide
Oxygen