Oxygen-dependent reduction of a nitroxide free radical by electron paramagnetic resonance monitoring of circulating rat blood

Biochim Biophys Acta. 1993 Aug 4;1182(1):115-8. doi: 10.1016/0925-4439(93)90161-s.

Abstract

The effects of fraction of inspired oxygen (FiO2) on the reduction of a nitroxide free radical were studied by X-band electron paramagnetic resonance (EPR) monitoring of circulating rat blood. The decay half-life of the metabolism/elimination phase increased significantly by 24 +/- 8% during hyperoxia and decreased significantly by 16 +/- 4% during hypoxia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cyclic N-Oxides / chemistry
  • Electron Spin Resonance Spectroscopy
  • Free Radicals
  • Hypoxia / blood*
  • Nitrogen Oxides / blood*
  • Nitrogen Oxides / chemistry
  • Oxidation-Reduction
  • Oxygen / blood*
  • Rats
  • Spin Labels

Substances

  • Cyclic N-Oxides
  • Free Radicals
  • Nitrogen Oxides
  • Spin Labels
  • proxyl nitroxide
  • Oxygen