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, 28 Suppl 5, 45-7

Effect of Lymphoblastoid Alfa-Interferon in Patients With Chronic Hepatitis C Having Different Genotypic Subtype of Hepatitis C Virus

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Effect of Lymphoblastoid Alfa-Interferon in Patients With Chronic Hepatitis C Having Different Genotypic Subtype of Hepatitis C Virus

K Chayama et al. Gastroenterol Jpn.

Abstract

Five subtypes of hepatitis C virus (Pt[I], K1[II], K2a[III], K2b[IV] and Tr[V]) have been suggested based on the nucleotide sequence of the non-structural five region. To assess the susceptibility of each subtype to interferon therapy, we developed a one-step method which allows quick determination of subtype using polymerase chain reaction with a mixed primer set deduced from the sequence of each subtype. We were able to determine the subtype of 69 of 80 (86.3%) Japanese patients who received natural alfa-interferon treatment. The incidence of each subtype was K1: 53 (76.8%), K2a: 14 (20.3%), K2b: 3 (4.3%) and Tr: 1 (1.4%). Interferon was administered to these patients and found to be effective in 28 of 51 (54.9%) patients with K1 subtype and in 16 of 18 (88.9%) patients with other subtypes (P < 0.01). These data show that K1 is a major subtype in Japan and relatively resistant to interferon treatment.

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