Abstract
Some fused pyridazino[4,5-b]indoles (7) were synthesized. These new compounds present a planar topography and some resemblance to carbazeram, imadozan, and other pyridazino agents with cardiotonic activity. These compounds also possess a complementary effect as inhibitors of platelet aggregation. 6-(3,5-Dimethylpyrazolyl)-1,2,4-triazolo[4,3-b]pyridazino[4, 5-b]indole (7a) has a good profile as an inodilatador with antiaggregate activity due to the inhibition of phosphodiesterase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
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Animals
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Aorta, Thoracic / drug effects
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Blood Platelets / drug effects
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Blood Platelets / enzymology
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Cardiotonic Agents / chemical synthesis*
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Cardiotonic Agents / pharmacology
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Dogs
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Female
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Guinea Pigs
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Heart / drug effects
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Humans
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In Vitro Techniques
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Indoles / chemical synthesis*
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Indoles / pharmacology
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Isoenzymes / antagonists & inhibitors
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Male
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Myocardium / enzymology
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Phosphodiesterase Inhibitors / pharmacology
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / chemical synthesis
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Platelet Aggregation Inhibitors / pharmacology
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Pyridazines / chemical synthesis*
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Pyridazines / pharmacology
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Rats
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Rats, Wistar
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Structure-Activity Relationship
Substances
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Cardiotonic Agents
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Indoles
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Isoenzymes
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Phosphodiesterase Inhibitors
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Platelet Aggregation Inhibitors
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Pyridazines
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3',5'-Cyclic-AMP Phosphodiesterases