Effect of saiboku-to (TJ-96) on bronchial asthma. Induction of glucocorticoid receptor, beta-adrenaline receptor, IgE-Fc epsilon receptor expression and its effect on experimental immediate and late asthmatic reaction

Ann N Y Acad Sci. 1993 Jun 23;685:549-60. doi: 10.1111/j.1749-6632.1993.tb35918.x.

Abstract

A remarkable "steroid sparing" effect of Saiboku-to was noted within 6 to 12 months of treatment in steroid-dependent asthmatic patients. Saiboku-to spared the downregulation of glucocorticoid receptor of human lymphocytes, plasma ACTH, and cortisol levels. It also spared downregulation of beta 2 receptor by beta 2 agonists and suppressed mACh receptor at the same time. Saiboku-to increased tyrosine aminotransferase (TAT) production, which was inhibited by actinomycin-D, thus having steroid-like activity. In mite-allergic asthma, Saiboku-to inhibited the induction of expression of IgE-Fc epsilon R/CD23 in the lymphocytes by mite allergen. It also inhibited IgE production by mite allergens. In experimental asthma in guinea pigs the use of Saiboku-to resulted in a decrease in the number of eosinophils in the bronchoalveolar lavage fluid during late asthmatic response. These findings suggest that Saiboku-to may be effective in inhibiting both the expression of IgE-Fc epsilon R2 and the induction of expression of IgE-Fc epsilon R1. Saiboku-to also has a steroid-like action and polyhedral anti-asthmatic activities.

MeSH terms

  • Animals
  • Asthma / drug therapy*
  • Asthma / immunology
  • Drugs, Chinese Herbal / pharmacology*
  • Drugs, Chinese Herbal / therapeutic use
  • Guinea Pigs
  • Humans
  • Immunoglobulin E / biosynthesis
  • Immunosuppressive Agents / pharmacology*
  • Lymphocyte Activation / drug effects
  • Medicine, Kampo*
  • Receptors, Adrenergic, beta / analysis
  • Receptors, Adrenergic, beta / drug effects*
  • Receptors, Glucocorticoid / analysis
  • Receptors, Glucocorticoid / drug effects*
  • Receptors, IgE / analysis
  • Receptors, IgE / drug effects*

Substances

  • Drugs, Chinese Herbal
  • Immunosuppressive Agents
  • Receptors, Adrenergic, beta
  • Receptors, Glucocorticoid
  • Receptors, IgE
  • saiboku-to
  • Immunoglobulin E