Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation

Am J Physiol. 1993 Aug;265(2 Pt 1):E230-5. doi: 10.1152/ajpendo.1993.265.2.E230.

Abstract

The effect of correction of acidosis in chronic renal failure (CRF) was determined from the kinetics of infused L-[1-13C]leucine. Nine CRF patients were studied before (acid) and after two 4-wk treatment periods of sodium bicarbonate (NaHCO3) and sodium chloride (NaCl) (pH: acid 7.31 +/- 0.01, NaHCO3 7.38 +/- 0.01, NaCl 7.30 +/- 0.01). Leucine appearance from body protein (PD), leucine disappearance into body protein (PS) and leucine oxidation (O) decreased significantly with correction of acidosis (PD: acid 122.4 +/- 6.1, NaHCO3 88.3 +/- 6.9, NaCl 116.2 +/- 9.1 mumol.kg-1.h-1, acid vs. NaHCO3 P < 0.01, NaHCO3 vs. NaCl P < 0.01, acid vs. NaCl NS; PS: acid 109.4 +/- 5.6, NaHCO3 79.0 +/- 6.3, NaCl 101.3 +/- 7.7 mumol.kg-1.h-1, acid vs. NaHCO3 P < 0.01, NaHCO3 vs. NaCl P < 0.01, acid vs. NaCl NS; O: acid 13.0 +/- 1.2, NaHCO3 9.2 +/- 0.9, NaCl 15.0 +/- 1.9 mumol.kg-1.h-1, acid vs. NaHCO3 P < 0.05, NaHCO3 vs. NaCl P < 0.01, acid vs. NaCl NS). There were no significant changes in plasma amino acid concentrations. These results confirm that correction of acidosis in chronic renal failure removes a potential catabolic factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acidosis / drug therapy*
  • Acidosis / etiology
  • Adolescent
  • Adult
  • Aged
  • Amino Acids / blood
  • Amino Acids / metabolism*
  • Bicarbonates / blood
  • Bicarbonates / therapeutic use*
  • Blood Glucose / analysis
  • Blood Pressure / drug effects
  • Body Weight / drug effects
  • Female
  • Hormones / blood
  • Humans
  • Hydrogen-Ion Concentration
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / metabolism*
  • Male
  • Middle Aged
  • Oxidation-Reduction
  • Proteins / metabolism*
  • Sodium / therapeutic use*
  • Sodium Bicarbonate
  • Sodium Chloride / pharmacology
  • Urea / blood

Substances

  • Amino Acids
  • Bicarbonates
  • Blood Glucose
  • Hormones
  • Proteins
  • Sodium Chloride
  • Sodium Bicarbonate
  • Urea
  • Sodium