The Induction of LTP Increases BDNF and NGF mRNA but Decreases NT-3 mRNA in the Dentate Gyrus

Neuroreport. 1993 Jul;4(7):895-8. doi: 10.1097/00001756-199307000-00014.

Abstract

We have investigated the expression of the mRNAs for brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) in the hippocampus before and after induction of long term potentiation (LTP) of synaptic transmission in the dentate gyrus through stimulation of the perforant path (PP). A unilateral PP stimulation produced a bilateral increase in the mRNA for both BDNF and NGF in granular neurones of the dentate gyrus but not in other neurones in the hippocampus. The mRNA for neurotrophin-3 (NT-3) was bilaterally decreased by LTP but that of NT-4 remained at the basal level. These results suggest that individual neurotrophic factors may play different roles in neuronal plasticity.

MeSH terms

  • Animals
  • Blotting, Northern
  • Brain-Derived Neurotrophic Factor
  • Electric Stimulation
  • Hippocampus / metabolism*
  • Hippocampus / physiology
  • In Situ Hybridization
  • Male
  • Nerve Fibers / physiology
  • Nerve Growth Factors / biosynthesis*
  • Nerve Tissue Proteins / biosynthesis*
  • Neuronal Plasticity / physiology*
  • Neurons / physiology
  • Neurotrophin 3
  • Protein-Tyrosine Kinases / biosynthesis
  • RNA, Messenger / biosynthesis*
  • Rats
  • Rats, Wistar
  • Synapses / physiology
  • Synaptic Transmission / physiology

Substances

  • Brain-Derived Neurotrophic Factor
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Neurotrophin 3
  • RNA, Messenger
  • Protein-Tyrosine Kinases
  • neurotrophin 4