Three adjacent genes of African swine fever virus with similarity to essential poxvirus genes

Arch Virol. 1993;132(3-4):331-42. doi: 10.1007/BF01309543.


Nucleotide sequencing of the right end of the SalIj fragment of the highly virulent Malawi Lil20/1 strain of African swine fever virus (ASFV) has revealed three adjacent genes with similarity to: serine-threonine protein kinases; members of the putative helicase superfamily SF2; and the vaccinia virus 56 kDa abortive late protein. All three genes are transcribed to the left with respect to the orientation of the ASFV genome. Gene L19IL predicts a protein similar to serine-threonine protein kinases including vaccinia virus gene B1R. Gene L19KL predicts a protein that is likely to be a nucleic acid-dependent ATPase, as it has similarity to both the poxvirus 70 kDa early transcription factor subunit and the poxvirus nucleoside triphosphatase I gene. Gene L19LL has extensive similarity to the vaccinia virus 56 kDa abortive late protein.

Publication types

  • Comparative Study

MeSH terms

  • African Swine Fever Virus / genetics*
  • Amino Acid Sequence
  • Base Sequence
  • Conserved Sequence
  • DNA Helicases / genetics
  • Genes, Lethal / genetics
  • Genes, Viral / genetics*
  • Molecular Sequence Data
  • Open Reading Frames / genetics
  • Poxviridae / genetics
  • Protein Serine-Threonine Kinases / genetics
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid


  • Protein Serine-Threonine Kinases
  • DNA Helicases

Associated data

  • GENBANK/M88275