Cancer vaccines

Immunol Today. 1993 Jun;14(6):310-6. doi: 10.1016/0167-5699(93)90051-L.


1993 represents the 100th anniversary of William Coley's first report of tumor regressions induced by immune system activation in response to bacterial toxins. While many subsequent cancer vaccine trials have yielded tantalizing results, active immunotherapy has not yet become an established modality of cancer therapy. Newer molecular vaccine approaches based on rational immunological principles have resulted in improved systemic antitumor effects in animal models. Ultimately the genetic definition of tumor-specific antigens will allow the development of targeted antigen-specific vaccines for cancer therapy.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / therapeutic use
  • Animals
  • Antigens, Neoplasm / immunology*
  • Combined Modality Therapy
  • Cytokines / genetics
  • Cytokines / therapeutic use
  • Humans
  • Immunotherapy, Active*
  • Major Histocompatibility Complex / genetics
  • Major Histocompatibility Complex / immunology
  • Neoplasms / immunology
  • Neoplasms / therapy*
  • Vaccines, Synthetic / therapeutic use*


  • Adjuvants, Immunologic
  • Antigens, Neoplasm
  • Cytokines
  • Vaccines, Synthetic