Radiographic changes associated with tracheal isolation of Ureaplasma urealyticum from neonates

Clin Infect Dis. 1993 Aug;17 Suppl 1:S122-30. doi: 10.1093/clinids/17.supplement_1.s122.


Recent studies show an association between the presence of Ureaplasma urealyticum in tracheal aspirates and bronchopulmonary dysplasia. We hypothesized that among infants with birth weights < or = 1,250 g and respiratory disease, those with U. urealyticum in their tracheal aspirates would have radiographic evidence of more-severe pulmonary disease more often than would those without this organism. A total of 292 low-birth-weight infants who had endotracheal aspirate cultured within 7 days of birth were enrolled. The radiographic outcome variables were pneumonia, early severe bronchopulmonary dysplasia (precocious), and chronic lung disease. Microorganisms were isolated from 128 infants (44%); U. urealyticum was isolated from 44 (15%). Pneumonia was significantly more common in infants with than without U. urealyticum (30% vs. 16%, P = .03). U. urealyticum also was associated with precocious bronchopulmonary dysplasia independent of prematurity, race, and sex (odds ratio, 2.2; P < .05). Tracheal isolation of U. urealyticum within 7 days of birth is associated with pneumonia and precocious bronchopulmonary dysplasia.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bronchopulmonary Dysplasia / diagnostic imaging*
  • Bronchopulmonary Dysplasia / etiology
  • Bronchopulmonary Dysplasia / microbiology
  • Female
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Pneumonia / complications
  • Radiography
  • Trachea / microbiology*
  • Ureaplasma Infections / complications
  • Ureaplasma urealyticum / isolation & purification*
  • Ureaplasma urealyticum / pathogenicity