Tumour cyclic AMP binding proteins: an independent prognostic factor for disease recurrence and survival in breast cancer

Breast Cancer Res Treat. 1993;26(1):89-94. doi: 10.1007/BF00682703.


In two separate cohorts of breast cancer patients presenting without evidence of distant metastatic disease, high levels of tumour cyclic AMP binding proteins (> 8 pmol/mg cytosol protein) have been shown to be associated with poor prognosis in terms of both disease recurrence and overall survival. This association is independent of known established prognostic factors and allows the identification of a small subgroup of patients whose outlook warrants the implementation of aggressive systemic therapy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Breast Neoplasms / epidemiology*
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Carrier Proteins
  • Cohort Studies
  • Cyclic AMP Receptor Protein / metabolism*
  • Female
  • Humans
  • Lymphatic Metastasis
  • Multivariate Analysis
  • Neoplasm Proteins / metabolism*
  • Neoplasm Recurrence, Local / metabolism*
  • Prognosis
  • Protein Binding
  • Survival Analysis


  • Carrier Proteins
  • Cyclic AMP Receptor Protein
  • Neoplasm Proteins