The ovine Booroola fecundity gene (FecB) is linked to markers from a region of human chromosome 4q

Nat Genet. 1993 Aug;4(4):410-4. doi: 10.1038/ng0893-410.


The autosomal Booroola fecundity gene (FecB) mutation in sheep increases ovulation rate and litter size, with associated effects on ovarian physiology and hormone profiles. Analysis of segregation in twelve families (379 female progeny) identified linkage between the mutation, two microsatellite markers (OarAE101 and OarHH55, Zmax > 9.0) and epidermal growth factor (EGF) from human chromosome 4q25 (Zmax > 3.0). The marker OarAE101 was linked to secreted phosphoprotein 1 (SPP1, which maps to chromosome 4q21-23 in man) in the test pedigrees and independent families (Zmax > 9.7). The identification of linkage between the FecB mutation and markers from human chromosome 4q is an important step towards further understanding the control of ovulation rates in mammals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 4*
  • DNA Probes
  • DNA, Satellite / genetics
  • Female
  • Fertility / genetics*
  • Genetic Linkage
  • Genetic Markers
  • Genotype
  • Humans
  • Male
  • Molecular Sequence Data
  • Mutation*
  • Oligodeoxyribonucleotides
  • Phenotype
  • Recombination, Genetic
  • Sheep / genetics*


  • DNA Probes
  • DNA, Satellite
  • Genetic Markers
  • Oligodeoxyribonucleotides