Germ-line p53 mutation is uncommon in patients with triple primary cancers

Cancer Lett. 1993 Sep 15;73(1):51-7. doi: 10.1016/0304-3835(93)90187-e.


We examined five patients with multiple primary cancers who had a history of three different types of primary cancers for germ-line p53 mutations. The germ-line p53 mutation was detected in a patient who conformed to the Li-Fraumeni syndrome, but not in the other four patients. The diagnosis of these four patients did not fall in the category of Li-Fraumeni syndrome. This result indicates that germ-line p53 mutations are uncommon even in patients with triple primary cancers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Genes, p53 / genetics*
  • Germ-Line Mutation
  • Humans
  • Li-Fraumeni Syndrome / genetics
  • Male
  • Neoplasms, Multiple Primary / genetics*