The putative tumor suppressor gene on chromosome 5q for hepatocellular carcinoma is distinct from the MCC and APC genes

Cancer Detect Prev. 1993;17(3):405-9.


We have previously shown that the tumor suppressor gene for hepatocellular carcinoma (HCC) without cirrhosis may be located on chromosome 5q35-qter. In this study, we analyzed nine cases of primary HCC without cirrhosis using probes from the MCC and APC genes, which are in the region 5q21-22. None of the informative cases had allele loss detected by these probes, whereas the probe lambda MS8 for the region 5q35-qter showed allele loss in six out of six informative cases. The results confirm that the putative tumor suppressor gene for HCC without cirrhosis on chromosome 5q is distinct from the MCC and APC genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Carcinoma, Hepatocellular / genetics*
  • Chromosome Deletion*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 5*
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / secondary
  • DNA Probes
  • Genes, APC
  • Genes, MCC
  • Genes, Tumor Suppressor / genetics*
  • Humans
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / secondary


  • DNA Probes