Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones

Cell. 1993 Oct 22;75(2):217-27. doi: 10.1016/0092-8674(93)80064-l.


Repulsive guidance cues can steer neuronal growth cones during development and prevent mature axons from regenerating. We have identified a 100 kd glycoprotein in the chick brain that is a good candidate for a repulsive cue. Since it induces the collapse and paralysis of neuronal growth cones in vitro, we have named it collapsin. It is effective at concentrations of approximately 10 pM. The C-terminal half of collapsin contains a single immunoglobulin-like domain and an additional highly basic region. The N-terminal half of collapsin shares significant homology with fasciclin IV, a growth cone guidance protein in grasshopper. Recombinant collapsin causes sensory ganglion growth cones to collapse but not retinal ganglion cell growth cones. We propose that collapsin could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain Chemistry*
  • Cells, Cultured
  • Chickens
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • Ganglia / growth & development
  • Ganglia, Sensory / growth & development
  • Glycoproteins / genetics
  • Glycoproteins / isolation & purification
  • Glycoproteins / pharmacology*
  • Molecular Sequence Data
  • Neurons / physiology*
  • Organ Culture Techniques
  • Organ Specificity
  • Recombinant Proteins / biosynthesis
  • Recombinant Proteins / pharmacology
  • Retina / growth & development
  • Semaphorin-3A
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid


  • DNA, Complementary
  • Glycoproteins
  • Recombinant Proteins
  • Semaphorin-3A

Associated data

  • GENBANK/L20888
  • GENBANK/L20889
  • GENBANK/L26083
  • GENBANK/L33709
  • GENBANK/S60904
  • GENBANK/S60905
  • GENBANK/S60924
  • GENBANK/S66168
  • GENBANK/U00968
  • GENBANK/U02528