Localization of the transcription factor SP1 gene to human chromosome 12q12-->q13.2

R B Gaynor; B H Shieh; I Klisak; R S Sparkes; A J Lusis

doi:10.1159/000133578

Localization of the transcription factor SP1 gene to human chromosome 12q12-->q13.2

Cytogenet Cell Genet. 1993;64(3-4):210-2. doi: 10.1159/000133578.

Authors

R B Gaynor¹, B H Shieh, I Klisak, R S Sparkes, A J Lusis

Affiliation

¹ Department of Medicine and Microbiology, University of Texas Southwestern Medical School, Dallas 75235-8594.

PMID: 8404040
DOI: 10.1159/000133578

Abstract

The cellular transcription factor SP1 binds to critical regulatory elements in a variety of cellular and viral promoters. The gene encoding the approximately 100-kDa SP1 protein contains zinc finger DNA-binding domains and glutamine-activation domains. Since SP1 is involved in the regulation of a variety of cellular genes, we wished to determine its chromosomal localization. Southern blot analysis of genomic DNA from a panel of mouse x human somatic cell hybrids indicated that SP1 was localized to chromosome 12. In situ hybridization allowed the localization of the gene encoding SP1 to human chromosome 12q12-->q13.2, with 12q13.1 being the most probable location.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Chromosome Mapping
Chromosomes, Human, Pair 12*
Humans
Hybrid Cells
In Situ Hybridization
Male
Mice
Sp1 Transcription Factor / genetics*

Substances

Sp1 Transcription Factor

Grants and funding

etc