Treatment options for patients with iatrogenic esophageal perforations are multiple and remain a source of controversy. Therapeutic options range from conservative, non-operative treatment to esophageal exclusion or esophagectomy. We present herein what we believe to be the first described repair of an esophageal perforation using thoracoscopic surgical techniques. We believe this approach offers several advantages over open thoracic surgery and has a role in minimizing postoperative morbidity in an already potentially life-threatening condition.