An interaction of beta-amyloid with aluminium in vitro

FEBS Lett. 1993 Jun 21;324(3):293-5. doi: 10.1016/0014-5793(93)80137-j.

Abstract

We have used circular dichroism spectroscopy to confirm that, in a membrane-mimicking solvent, A beta P(1-40) adopts a partially helical conformation and we have demonstrated the loss of this structure in the presence of physiologically relevant concentrations of aluminium. This is the first evidence of a direct biochemical interaction between aluminium and beta-amyloid and may have important implications for the pathogenesis of Alzheimer's disease.

MeSH terms

  • Aluminum / chemistry*
  • Amyloid beta-Peptides / chemistry*
  • Circular Dichroism
  • Humans
  • In Vitro Techniques
  • Peptides / chemistry
  • Protein Structure, Secondary

Substances

  • Amyloid beta-Peptides
  • Peptides
  • Aluminum